Assessment of Total Procollagen Type 1 Intact N-terminal Propeptide, C-telopeptide of type 1 collagen, Bone Mineral Density and its Relationship to Body Mass Index in Men with Type 2 Diabetes

Background: Type 2 diabetes negatively affects the biochemical parameters of bone turnover more than obesity and is associated with an increased risk osteoporosis fragility fractures. Obesity type (T2DM) are linked to fracturing risk; however, effect on diabetes-related deficit unknown. Objective: The goal this research compare indications, density, in T2DM men a control group, investigate body mass index levels. Subjects, Material Method: This case-control study was conducted 120 whose ages were from 40 - 69 years. They grouped into two categories: (n=80) healthy (n=40). Serum samples both groups analyzed for blood glucose, Calcium Albumin, by using (Cobas c111), PTH e 411), P1NP CTX-1 levels serum ELISA kits. Participants underwent (DEXA) measuring Bone Mass Density (BMD) at lumbar spine. Results: (obese non-obese) participants had statistically significant higher patients (P-value = 0.000). There no differences Spine BMD, T-score (p-value 0.27 0.37 respectively). Conclusion: Men low level deteriorated quality compared controls. obese controls can maintain metabolism if prevented.